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Understanding the Link Between Roundup and Non-Hodgkin’s Lymphoma

Kvekhdria Pyrnathos June 2, 2025 3 min read
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Roundup, the most widely applied herbicide globally, has been a fixture of agriculture and homeowner weed control for decades. Recently, mounting evidence has been raising concerns about its possible association with severe disease, notably non-Hodgkin lymphoma (NHL), a form of cancer of the lymphatic system.

This growing concern has led to numerous legal cases, primarily the Roundup lawsuit. Most plaintiffs claim that their long-term exposure to glyphosate led to their contracting NHL. Many lawsuits argue that Monsanto, the producer of Roundup, did not label the product appropriately about its potential for causing cancer.

As the cases have advanced, they have raised serious issues about corporate responsibility, scientific research, and regulatory oversight of herbicides.

The Glyphosate Controversy and Non-Hodgkin Lymphoma

Glyphosate, the main ingredient in Roundup, is a herbicide used to control weeds in farming, gardening, and lawn care. While it has been a success, there have been issues with its health consequences over the last few years. There are several studies suggesting that there is possibly a link between prolonged exposure to glyphosate and the development of non-Hodgkin lymphoma (NHL), which is a cancer of the lymph system.

The Roundup and non-Hodgkin lymphoma (NHL) link exists because of the concerns related to glyphosate, the active ingredient, on human cells. Specific research claims that long-term exposure to glyphosate can lead to cancerous transformation of the lymphatic system, although proof is still under investigation.

The World Health Organization-affiliated International Agency for Research on Cancer labeled glyphosate “probably carcinogenic to humans” in 2015. It has sparked a controversy over a possible heightened risk for NHL and produced many lawsuits against Roundup manufacturer Monsanto. Most of the plaintiffs in the litigation claimed that exposure to herbicides caused them to contract NHL.

Mechanisms Behind Glyphosate’s Carcinogenic Potential

Glyphosate kills plants by inhibiting a plant growth enzyme that does not exist in humans. But other studies have shown that glyphosate can interfere with human cellular processes indirectly, namely in immune cells, and this may potentially raise the cancer risk, albeit a matter of scientific debate.

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Other researchers speculate that glyphosate may interfere with DNA repair or cause oxidative stress, which can lead to cellular damage and cancer. Glyphosate is also mixed with other chemicals that will enhance its toxicity. These conditions suggest that long-term exposure to glyphosate, particularly for those who handle it or reside in communities with high agricultural application, may elevate the risk of developing NHL.

Legal Implications and Lawsuits

Thousands of plaintiffs have brought suits, claiming that glyphosate in Roundup caused their non-Hodgkin lymphoma (NHL). Numerous suits allege that Monsanto, now owned by Bayer, failed to warn consumers adequately of the risks. In some high-profile cases, juries have granted significant damage awards to plaintiffs, holding Monsanto liable for failing to reveal the cancer risk of glyphosate.

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The court cases have also raised alarm over corporate responsibility and state control. Even though the U.S. Environmental Protection Agency (EPA) approved glyphosate for use, rising evidence of a link to cancer has caused widespread concern. The cases also raise the impact of scientific studies on rules, with critics claiming that research sponsored by companies has downplayed the risks of glyphosate.

What the Future Holds: Research and Regulatory Action

Since the suits are pending, Roundup’s possible connection to non-Hodgkin lymphoma remains unaddressed. Additional research needs to be done on the side effects of long-term glyphosate exposure, and regulatory bodies worldwide are still assessing its safety.

In America, the Environmental Protection Agency (EPA) reports that glyphosate is safe when used correctly, but others, like the IARC and California, have been less optimistic. For example, California regulates glyphosate as a cause of cancer under Proposition 65. In Europe, herbicides continue to be licensed, but several nations are starting to enforce tighter controls.

The longer the controversy continues, the more Roundup consumers question the product’s safety and look for safer alternatives. Home gardeners and farm businesses are shifting increasingly towards organic and safer weed control alternatives, demonstrating that more are worried about glyphosate’s potential impact on human health.

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